Effects of concentrated growth factors on relieving postoperative reaction of guided bone regeneration in the esthetic zone / 华西口腔医学杂志

OBJECTIVE@#To explore the effect of concentrated growth factors (CGF) on postoperative pain and swelling in patients with complex dental implants.@*METHODS@#A total of 28 patients with single maxillary anterior teeth loss and labial orbital bone defect were recruited randomly and divided into two groups. Each group included 14 patients. The experimental group was applied with CGF membrane to guide bone regeneration, whereas the control group was treated with collagen membrane to guide bone regeneration. The postoperative pain degree and swelling degree were compared, and data were analyzed with SPSS 23.0 software. Postoperative pain was measured by visual analogue scale (VAS), and the degree of swelling was divided into four grades according to swelling range.@*RESULTS@#VAS scores of patients in experimental and control groups reached 35.1±22.5 and 47.0±20.3, respectively. The duration of postoperative pain in experimental and control groups totaled (2.1±1.5) and (2.8±1.0) days, respectively. No statistically significant difference was observed between the two groups (P>0.05). Percentages of non-swelling, mild swelling, moderate swelling, and severe swelling in experimental group reached 21.4%, 57.1%, 21.4%, and 0, respectively, and those in control group were 7.1%, 35.7%, 35.7%, and 21.4%. Swelling duration reached (2.4±1.4) and (4.2±2.2) days in the experimental and control groups, respectively. A statistically significant difference was observed in the swelling degree of experimental and control groups (P<0.05).@*CONCLUSIONS@#The use of CGF can significantly reduce the degree of postoperative swelling and shorten swelling time but cause no significant effect on pain.

Clinical evaluation of the socket-shield technique for immediate implantation in the maxillary anterior region / 华西口腔医学杂志

OBJECTIVE@#This study aimed to evaluate the clinical effect of the socket-shield technique in the maxillary anterior region at one year after implant placement.@*METHODS@#Ten patients with maxillary anterior teeth that cannot be reserved were enrolled. Implants were installed following the socket-shield technique and restored six months after the surgery. The thickness of the labial maxillary bone of the implant was compared before and one year after the surgery. At one year follow-up, the reten-tion rate of the implants, Jemt classification, and pink and white aesthetic scores were evaluated. Postoperative complications and patient satisfaction were also analyzed.@*RESULTS@#One year after installation, the retention rate of the implant was 100%. The thickness of the maxillary bone at the neck, central, and root section of the implant reduced to (0.27±0.21), (0.19±0.20), and (0.28±0.29) mm, respectively, compared with the values immediately after the operation. The thickness of the labial maxillary bone at the three measurement points immediately after and one year after the operation was statistically significant (P0.05) of the difference thickness between immediate and one year after operation at the three measurement points. The pink esthetic scores of the implant prosthesis was 9.10±0.54, and the white esthetic scores was 9.00±0.63. No complications were observed, and the patients had a high degree of satisfaction.@*CONCLUSIONS@#The socket-shield technique could provide acceptable treatment results but cannot completely avoid the reconstruction of the labial maxillary bone of the implants. The technique exhibits favo-rable short-term aesthetic result, but its long-term clinical effect and aesthetic problems need to be further studied.

Contributions of endothelin in the process of the noise-induced injury of inner ear / 中华耳鼻咽喉头颈外科杂志

<p><b>OBJECTIVE</b>To study the pathological alteration of the cochlear microcirculation and the role of endothelin (ET) in the process of the noise-induced injury of inner ear.</p><p><b>METHODS</b>Thirty rats were randomly divided into five groups: control group and 1, 4, 8, 15 d noise exposure groups (115 dB, white noise, 8 h daily). The cilium of hair cell was observed by scanning electron microscope, the cochlear microcirculation was determined by stretched preparation of the stria vascularis. The level of ET in plasma was measured through radio-immunity. The distribution of ET-1, ETA, ETB, in cochlea were detected through immunohistochemistry staining.</p><p><b>RESULTS</b>In the 4, 8, 15 d group, severe ischemia appeared on the capillary of stria vascularis and the cilium of hair cell displayed significantly disorder. The level of ET in plasma rose temporarily in the 4 d group. ET-1 activity distributed widely in the rat cochlea, there was no significant difference between the control group and the noise exposure groups. ETA expressed in the plasma of the intermediate cells and the capillary walls in the stria vascularis. The control group and the 1 d group showed weak positive staining, while the 4, 8, 15 d groups showed strong positive. The ETB, activity distributed on the endothelial cells of the capillary of stria vascularis and the alteration of the staining intensity was similar to the manifestation of ETA.</p><p><b>CONCLUSIONS</b>Severe disturbance of the cochlear circulation occurred during the course of the noise injury to the inner ear. At the same time, the activity of the ET system of the cochlea stepped up significantly. It coincided with the ischemia of the stria vascularis. These findings suggest that ET may play an important role in the process of the cochlear microcirculation disorder caused by noise.</p>